Expanding the molecular understanding, and advancing personalised therapeutics for KIF1A-Associated Neurological Disorders
- Research Opportunity
- PhD students
- Department / Centre
- Royal Children’s Hospital/Murdoch Childrens Research Institute
|Dr Simranpreet Kauremail@example.com||03-83416268||Personal web page|
|Prof John Christodouloufirstname.lastname@example.org||Personal web page|
|A/Prof Wendy Goldemail@example.com|
Summary Background Kinesin-3 family member 1A (KIF1A) encodes a neuron-specific kinesin motor protein essential for ATP-dependent anterograde axonal transport of synaptic cargos along the microtubule network in brain cells. The N-terminal motor domain of KIF1A forms the “head” that “walks” along the microtubules in a stepwise manner for anterograde transportation of specific cargos docked at the C-terminal “tail” domain using energy from ATP hydrolysis. Variants in the KIF1A gene have been found to result in a complex spectrum of neurodegenerative conditions, collectively referred to as KIF1A-associated neurological disorders (KANDs). In this proposal, we will address a wide gap in our understanding of KIF1A at the molecular and therapeutic level. Success in this project has the scope to accelerate the long-term vision of scientific therapeutics-based research to improve the health of children battling with the progressive KAND disorder and related neurological disorders.
Faculty Research Themes
School Research Themes
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
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Department / Centre
Research Group / Unit / Centre
Research NodeRoyal Children’s Hospital/Murdoch Childrens Research Institute
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