Examining A New Drug Target For Preventing Stomach Cancer

Research Opportunity
PhD
Department
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Professor Philip Sutton phil.sutton@mcri.edu.au +61399366751
Co-supervisor Email Number Webpage
Ms Sohinee Sarkar sohinee.sarkar@mcri.edu.au +61399366624

Project Details

Stomach cancer (gastric adenocarcinoma) is the fifth most common cancer in the world and the third leading cause of death due to malignancy. The vast majority of these cancers develop as a direct result of a chronic gastritis (inflammation of the stomach) caused by infection with the spiral-shaped bacterium Helicobacter pylori. These bacteria inhabit the specialised niche of the human stomach lining, where they infect approximately half the world's population. Infection with this pathogen drives an inflammatory response that lasts for decades; it is this inflammation which is the key driver in the development of stomach cancer.
We have identified a genetic polymorphism that considerably increases the chance of someone infected with H. pylori developing stomach cancer. This gene encodes a receptor expressed on the cell surface and when activated can modify the inflammatory response to bacteria. Moreover, drugs are already available that can modify the activity of this receptor.
This PhD project firstly aims to examine the polymorphism of this gene in order to understand how it modifies the activity of the receptor and thereby make some people more susceptible to cancer. Secondly it aims to examine the potential use of drug treatment in reducing H. pylori induced inflammation and thereby developing a novel treatment for preventing the development of stomach cancer.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

PhD
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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