Elucidating the Effect of Hyperglycaemia (Short and Long Term) on Bone and Muscle Quality and Metabolism

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Western Health
Primary Supervisor Email Number Webpage
Associate Professor Itamar Levinger itamar.levinger@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Professor Gustavo Duque gustavo.duque@unimelb.edu.au 03 8395 8121 Personal web page

Project Details

Increased bone fragility and reduced skeletal muscle quality are under-recognised complications of long-term hyperglycaemia in type 2 diabetes mellitus (T2DM). As a result, patients have an increased risk of falls, fractures, and a reduced quality of life. The effect of T2DM on bone structure and metabolism is not clear. Some reported that bone micro architectural parameters at the distal radius and tibia were not different between T2DM patients and BMI and age-matched controls while others have even reported improved trabecular microarchitecture. Most reports agree, however, that cortical porosity is increased and mineral strength is reduced in patients with T2DM. Patients with T2DM have reduced bone formation markers: procollagen type 1 N-terminal propeptide (P1NP), osteocalcin and alkaline phosphatase, and some evidence that resorption makers are reduced. In the case of muscle, high blood glucose is associated with fat infiltration and metabolic abnormalities that affect bone mass, strength and function. Whether these effects are due to the high glucose or insulin (hyperinsulinemia is common in T2DM, at least in early stages) is not clear. We hypothesise that bone metabolism and muscle mass and function are consequences of the suppressive effects of high blood glucose.


School Research Themes

Musculoskeletal



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Western Health

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