Elucidating molecular signalling pathways controlled by anti-inflammatory steroids

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department / Centre
Medicine
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Adrian Achuthan aaa@unimelb.edu.au 8344 3298 Personal web page

Summary Steroids (glucocorticoids) are widely used to treat the chronic inflammation and pain associated with many diseases such as rheumatoid arthritis and osteoarthritis. Unfortunately, there are side effects associated with usage of glucocorticoids in such diseases. Our previous genomic experiments have provided a number of exciting candidate genes that may be involved in inflammatory functions. In this project you will investigate molecular signalling pathways that lead to activation of transcription factors that lead to differential expression of glucocorticoid-controlled genes in inflammatory conditions. Enhancing our understanding of molecular signalling pathways that are governed by glucocorticoids may lead to improved clinical therapies with minimal side effects.

Project Details

Project description: Steroids (glucocorticoids) are widely used to treat the chronic inflammation and pain associated with many diseases such as rheumatoid arthritis and osteoarthritis. Unfortunately, there are side effects associated with usage of glucocorticoids in such diseases. Our previous genomic experiments have provided a number of exciting candidate genes that may be involved in inflammatory functions. In this project you will investigate molecular signalling pathways that lead to activation of transcription factors that lead to differential expression of glucocorticoid-controlled genes in inflammatory conditions. Enhancing our understanding of molecular signalling pathways that are governed by glucocorticoids may lead to improved clinical therapies with minimal side effects.

Techniques: You will acquire a wide-range of skills in cell biology (primary human monocyte/macrophage culture, ELISA assays, confocal microscopy and flow cytometry), and biochemistry and molecular biology (Western blotting, Real‐Time PCR and siRNA‐mediated gene knock-down).



Faculty Research Themes

Cancer, Infection and Immunology

School Research Themes

Cancer in Medicine, Cardiometabolic , Musculoskeletal



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine

Research Node

Royal Melbourne Hospital

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