Elucidating molecular signalling pathways controlled by anti-inflammatory steroids

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Adrian Achuthan aaa@unimelb.edu.au 8344 3298 Personal web page

Project Details

Project description: Steroids (glucocorticoids) are widely used to treat the chronic inflammation and pain associated with many diseases such as rheumatoid arthritis and osteoarthritis. Unfortunately, there are side effects associated with usage of glucocorticoids in such diseases. In this project you will use genome-wide approaches such as microarray to indentify the genes that are regulated by glucocorticoids. More specifically you will investigate molecular signalling pathways that lead to activation of transcription factors that lead to differential expression of glucocoritcoid-controlled genes in inflammatory conditions. Enhancing our understanding of molecular signalling pathways that are governed by glucocorticoids may lead to improved clinical therapies with minimal side effects.

Techniques: You will acquire a wide-range of skills in cell biology (primary human monocyte/macrophage culture, ELISA assays, confocal microscopy and flow cytometry), and biochemistry and molecular biology (Western blotting, Real‐Time PCR and siRNA‐mediated gene knock-down).



Faculty Research Themes

Infection and Immunology

School Research Themes

Musculoskeletal



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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