Electrophysiological Properties of Human Brain Neuronal Tissue

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Chris French frenchc@unimelb.edu.au 8344 3276 Personal web page

Project Details

Almost all electrophysiological observations of neural normal function, drug responsiveness and abnormal states such as epilepsy in have been performed on rodent brain tissue. It is becoming clear, however, that human tissue has significant differences from rodent brain.

This project presents an almost unique opportunity to study human brain tissue at the single neuron and network level by utilising tissue taken in the course of neurosurgical procedures. Individual neurons are prepared by enzymatic dissociation, and recorded with patch electrodes. Network properties are recorded using intact brain slice.

For this project, the main aims are to identify the properties of voltage gated ion channels, in particular sodium and potassium currents. An area of special interest is the HERG channel subtype, which is likely to play an important role in brain function, but almost completely uncharacterised in any neural system. Check out https://ndl-lab.org/home



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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