Effects of Drugs on Cognition-Related Brain Wave Signals in the Rodents

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Chris French frenchc@unimelb.edu.au 8344 3276 Personal web page

Project Details

It is increasingly recognised that the rhythmic signals recorded with the electroencephalogram (EEG), or “brain waves” are not just the “noise” of neural activity, but are probably frequency specific channels for cognition related signalling, including memory encoding.  High frequency (“gamma”) brain wave activity has been associated with cognitive activity in humans and animals, and is disrupted in psychosis and schizophrenia.

A largely neglected area of study in this area is the role of voltage-gated ion channels that have a significant role in the generation of neuronal and network rhythmicity.  In this project, signals related to cognitive processing, including gamma frequency oscillations and place cells will be recorded with microelectrode arrays. The effects of antipsychotic drugs and some related compounds, including potassium and sodium channel modulators, will be examined

This project has considerable potential to reveal how psychoactive drugs work at the whole brain level, and provide clues for better therapies. Check out https://ndl-lab.org/home


School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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