Effect of congenital UDT on Gonocyte development

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Doctor Ruili Li ruili.li@mcri.edu.au 99366757 Personal web page
Co-supervisor Email Number Webpage
Professor John Hutson john.hutson@mcri.edu.au 93455808 Personal web page

Summary The project will analyse the effect of congenital UDT on gonocyte transformation using animal models and or human biopsies. The study will involve the use of flow cytometry, immunohistochemistry, confocal microscopy, PCR.

Project Details

Undescended testis (UDT) is a major health problem, affecting over 2-4% of males at birth, and with a long-term risk of infertility (30-60%) and a 5-10 fold increase in testicular cancer in young men. Infertility and testicular cancer are likely caused by failed transformation of primitive sperm cells (gonocytes) into spermatogonial stem cells (SSC). Currently UDT surgery is recommended at 6-12 months, but it is not known whether this is the right time, as there is insufficient knowledge about early postnatal germ cell development. The project will analyse the effect of congenital UDT on gonocyte transformation using animal models and or human biopsies. The study will involve the use of flow cytometry, immunohistochemistry, confocal microscopy, PCR.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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