Effect of congenital UDT on Gonocyte development
- Research Opportunity
- Honours students, Master of Biomedical Science
- Number of Honour Places Available
- 1
- Number of Master Places Available
- 1
- Department / Centre
- Paediatrics
- Location
- Royal Children’s Hospital/Murdoch Childrens Research Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Doctor Ruili Li | ruili.li@mcri.edu.au | 99366757 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Professor John Hutson | john.hutson@mcri.edu.au | 93455808 | Personal web page |
Summary The project will analyse the effect of congenital UDT on gonocyte transformation using animal models and or human biopsies. The study will involve the use of flow cytometry, immunohistochemistry, confocal microscopy, PCR.
Project Details
Undescended testis (UDT) is a major health problem, affecting over 2-4% of males at birth, and with a long-term risk of infertility (30-60%) and a 5-10 fold increase in testicular cancer in young men. Infertility and testicular cancer are likely caused by failed transformation of primitive sperm cells (gonocytes) into spermatogonial stem cells (SSC). Currently UDT surgery is recommended at 6-12 months, but it is not known whether this is the right time, as there is insufficient knowledge about early postnatal germ cell development. The project will analyse the effect of congenital UDT on gonocyte transformation using animal models and or human biopsies. The study will involve the use of flow cytometry, immunohistochemistry, confocal microscopy, PCR.
Faculty Research Themes
School Research Themes
Research Opportunities
Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Node
Royal Children’s Hospital/Murdoch Childrens Research InstituteMDHS Research library
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