Drug delivery to treat hearing loss

Research Opportunity
PhD
Number of Honour Places Available
1
Department
Medical Bionics Department
Location
Bionics Institute
Primary Supervisor Email Number Webpage
A/Prof Andrew Wise awise@bionicsinstitute.org

Summary This project will focus on developing a treatment for hearing loss. We have recently made significant progress in the development of a nanoparticle-based drug delivery system that overcomes some of the barriers for drug delivery to the inner ear. The project will involve in vivo deafness models to characterise the drug delivery system, and to test its safety and efficacy in repairing hearing loss.

Project Details

Recent discoveries have shown that the synaptic connections between sensory hair cells and neurons in the inner ear are susceptible to damage from ageing and noise exposure. This type of damage leads to hearing impairment with particular problems of understanding speech in noisy environments, tinnitus and/or hyperacusis. There are currently no approved drug treatments that can prevent or repair hearing loss once it has occurred. This project will focus on developing a treatment for hearing loss. We have recently made significant progress in the development of a nanoparticle-based drug delivery system that overcomes some of the barriers for drug delivery to the inner ear. The project will involve in vivo deafness models to characterise the drug delivery system, and to test its safety and efficacy in repairing hearing loss. The project will use a diverse range of experimental techniques including drug pharmacokinetics, behavioral, electrophysiological and histological techniques.

General methods to be used in the project:
The project involves a multidisciplinary team of researchers with skills in biomedical and chemical engineering, molecular biology, systems physiology and clinical research.

Suitable background of students:
This PhD project will suit a student with a background in physiology, cell or molecular biology, biomedical science, or neuroscience background.



Faculty Research Themes

Neuroscience



Research Opportunities

PhD
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medical Bionics Department

Research Node

Bionics Institute

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