Do short chain fatty acids prevent gut leakiness and enhanced haematopoiesis induced by a high salt diet?

Research Opportunity
PhD students, Masters by Research, Honours students
Department / Centre
Baker Department of Cardiometabolic Health
Location
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Prof Andrew Murphy andrew.murphy@baker.edu.au
Co-supervisor Email Number Webpage
Dr. Sam Lee mankitsam.lee@baker.edu.au

Summary Our laboratory has discovered that a high salt diet promotes a breakdown of the intestinal barrier in the gut which causes activation of the immune system and changes within the bone marrow microenvironment, altering blood production. This project will explore the hypothesis that supplementation of butyrate, an anti-inflammatory short chain fatty acid, will prevent high salt diet-induced gut leakiness, immune cells activation and protect the bone marrow microenvironment from being destructed. This will allow for the retention of haematopoietic stem cells and normal blood production. This project will employ a variety of assays and experimental readouts to address this hypothesis and give the student a valuable insight into immune and stem cell biology within a highly successful world class research laboratory.

Project Details



Faculty Research Themes

School Research Themes

Cardiometabolic



Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

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