Do short chain fatty acids prevent gut leakiness and enhanced haematopoiesis induced by a high salt diet?
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Baker Department of Cardiometabolic Health
- Location
- Baker Heart and Diabetes Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Prof Andrew Murphy | andrew.murphy@baker.edu.au |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr. Sam Lee | mankitsam.lee@baker.edu.au |
Summary Our laboratory has discovered that a high salt diet promotes a breakdown of the intestinal barrier in the gut which causes activation of the immune system and changes within the bone marrow microenvironment, altering blood production. This project will explore the hypothesis that supplementation of butyrate, an anti-inflammatory short chain fatty acid, will prevent high salt diet-induced gut leakiness, immune cells activation and protect the bone marrow microenvironment from being destructed. This will allow for the retention of haematopoietic stem cells and normal blood production. This project will employ a variety of assays and experimental readouts to address this hypothesis and give the student a valuable insight into immune and stem cell biology within a highly successful world class research laboratory.
Project Details
Faculty Research Themes
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Baker Department of Cardiometabolic Health
Research Node
Baker Heart and Diabetes InstituteMDHS Research library
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