Development of novel vaccines against malaria

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Medicine and Radiology
Location
Burnet Institute
Primary Supervisor Email Number Webpage
Prof James Beeson beeson@burnet.edu.au 9282 2111 Personal web page
Co-supervisor Email Number Webpage
Dr Gaoqian Feng gaoqian.feng@burnet.edu.au 92822111

Summary This project is suitable for a student with a keen interest in humoral and cellular immunology and vaccine development.

Project Details

Development of a highly effective vaccine against malaria is greatly needed for global elimination of malaria. However, currently this is hindered because of a limited knowledge of the mechanisms and specific targets of immunity to malaria. We have used a wide range of approaches to identify mechanisms involving antibody interactions with Fc-receptors, immune cells, and complement, and antibody blocking of receptor-ligand interactions, which may be crucial for effective immunity against malaria.

This project will use our recently developed technologies and approaches to identify targets and epitopes that induce functional antibodies. The project will focus on key antigens expressed by malaria during its initial invasion stage. The project will involve the use of multiple cellular, molecular, and antibody assays to identify potential targets that could be included in vaccines. Studies will also investigate the optimal combinations of antibody targets that induce functional immunity in a synergistic manner, and using this knowledge for informing vaccine design and the expression and testing of novel vaccine candidates to achieve high levels of protection from malaria.

This project is suitable for a student with a keen interest in humoral and cellular immunology and vaccine development. The student will acquire unique skills in performing immunoassays including ELISA, monocyte/neutrophil isolation, flow-cytometry and immune-fluorescent staining, phagocytosis assays, as well as standard techniques in cell culture and analysing data from population studies. The specific activities and focus of the project will be refined to suit the interests and training background of the student.



Faculty Research Themes

Infection and Immunology

School Research Themes

Child Health in Medicine



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Burnet Institute

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