Development of malaria transmission blocking drugs.

Research Opportunity
PhD students, Masters by Research, Honours students
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Infectious Diseases
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Matthew Dixon matthew.dixon@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Prof James McCarthy james.mccarthy@unimelb.edu.au Personal web page

Summary Our laboratory investigates the cellular mechanisms underpinning malaria parasite transmission and disease. We investigate the novel banana shaped sexual stages of Plasmodium falciparum, focused on understanding their unique biology and how this contributes to transmission. We are interested in developing and testing drugs and vaccines that may block transmission of the parasite from infected humans to Anopheles mosquitos.

Project Details

The gametocyte stages of development represent a bottle neck in the malaria lifecycle with only a proportion (~10%) of the parasite population committing to sexual development.  This makes the gametocyte an attractive drug target, as disruption of gametocyte development by a drug or vaccine would stop transmission. Using a combination of iin vitro iand ex vivo experiments and examination of ex vivo samples from experimental malaria infection studies, we will investigate the effects these drugs and vaccines have on male and female gametocytes.  In addition, we will directly test how drug treatment effects transmission by mosquitos. The development and study of transmission blocking drugs and vaccines will be essential in the fight to eliminate malaria.



Faculty Research Themes

Infection and Immunology

School Research Themes

Child Health in Medicine



Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Infectious Diseases

Research Node

Royal Melbourne Hospital

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