Development of malaria transmission blocking drugs.
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Number of Honour Places Available
- Number of Master Places Available
- Department / Centre
- Infectious Diseases
- Royal Melbourne Hospital
|Dr Matthew Dixonfirstname.lastname@example.org||Personal web page|
|Prof James McCarthyemail@example.com||Personal web page|
Summary Our laboratory investigates the cellular mechanisms underpinning malaria parasite transmission and disease. We investigate the novel banana shaped sexual stages of Plasmodium falciparum, focused on understanding their unique biology and how this contributes to transmission. We are interested in developing and testing drugs and vaccines that may block transmission of the parasite from infected humans to Anopheles mosquitos.
The gametocyte stages of development represent a bottle neck in the malaria lifecycle with only a proportion (~10%) of the parasite population committing to sexual development. This makes the gametocyte an attractive drug target, as disruption of gametocyte development by a drug or vaccine would stop transmission. Using a combination of iin vitro iand ex vivo experiments and examination of ex vivo samples from experimental malaria infection studies, we will investigate the effects these drugs and vaccines have on male and female gametocytes. In addition, we will directly test how drug treatment effects transmission by mosquitos. The development and study of transmission blocking drugs and vaccines will be essential in the fight to eliminate malaria.
Faculty Research Themes
School Research Themes
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research NodeRoyal Melbourne Hospital
MDHS Research library
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