Development and characterisation of an animal model of neurological heterotopic ossification
- Research Opportunity
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
Neurological heterotopic ossification (NHO) is characterised by the formation of bone in soft tissue following a neurological condition. NHO frequently occurs following a traumatic brain injury and concomitant peripheral injury and often forms around the hip, knee and shoulder joints, causing severe pain and joint deformation, which is associated with significant morbidity and reduced quality of life. The mechanisms through which a TBI facilitates ectopic bone formation are incompletely understood, and as such pharmaceutical interventions to prevent the development of NHO have shown limited efficacy. This is in large part due to the challenges and limitations involved in studying this condition in humans. Animal models allow for the control of these confounds. Therefore, here we aim to develop and characterise a rat model of traumatic brain injury induced NHO that mimics both the injuries and pathologies observed in patients with NHO.
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