Development and characterisation of an animal model of neurological heterotopic ossification

Research Opportunity
Number of Honour Places Available
Medicine and Radiology
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Rhys Brady
Co-supervisor Email Number Webpage
A/Prof Sandy Shultz

Project Details

Neurological heterotopic ossification (NHO) is characterised by the formation of bone in soft tissue following a neurological condition. NHO frequently occurs following a traumatic brain injury and concomitant peripheral injury and often forms around the hip, knee and shoulder joints, causing severe pain and joint deformation, which is associated with significant morbidity and reduced quality of life. The mechanisms through which a TBI facilitates ectopic bone formation are incompletely understood, and as such pharmaceutical interventions to prevent the development of NHO have shown limited efficacy. This is in large part due to the challenges and limitations involved in studying this condition in humans. Animal models allow for the control of these confounds. Therefore, here we aim to develop and characterise a rat model of traumatic brain injury induced NHO that mimics both the injuries and pathologies observed in patients with NHO.

Faculty Research Themes


School Research Themes

Neuroscience & Psychiatry, Musculoskeletal

Research Opportunities

Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Node

Royal Melbourne Hospital

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