Developing nanoparticles for targeted theranostics delivery of drug and gene therapeutics

Research Opportunity
PhD students, Masters by Research
Number of Master Places Available
1
Department / Centre
Baker Department of Cardiometabolic Health
Location
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Dr Xiaowei Wang xiaoweiw@unimelb.edu.au +61385321495 Personal web page
Co-supervisor Email Number Webpage
Dr Laura Bienvenu laura.bienvenu@unimelb.edu.au

Summary Research in the Molecular Imaging and Theranostics lab focus on translational research that links the findings from basic science to the practical applications that enhance human health and well-being in clinical settings. Developing new bio-compatible nanoparticles that can be used for targeted delivery and localize the drugs/genetic therapy to the site of disease, thereby eliminating reduce side effects.

Project Details

Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Atherosclerosis, a chronic inflammatory disease, is the underlying cause of most CVDs. Therefore early detection, prevention or regression of atherosclerosis may prevent devastating events such as heart attacks from occurring.

We will create bio-compatible nanoparticles as contrast agents for imaging and drug carriers. These nanoparticles gives us the flexibility to incorporate drugs to increase their payload and/or apply them in gene delivery. By targeting these nanoparticles to the biomarkers of atherosclerosis, we can investigate their functions as novel theranostic (simultaneous diagnosis and therapy) approaches.

Therefore this project would also focus on Vascular Cell Adhesion Molecule-1, which is one of the endothelial surface molecules most strongly and specifically up-regulated in inflammation. We propose to conjugate VCAM-1 targeting recombinant antibodies onto nanoparticles for diagnosis imaging and targeted delivery of pharmacological or genetic treatment.

Significance: With steadily increasing health care expenses, targeted theranostic nanoparticles can provide early diagnosis and treatment of atherosclerosis, thereby preventing further CVDs.


School Research Themes

Cardiometabolic



Research Opportunities

PhD students, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

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