Developing interactome (Protein binding maps) maps for BRCA1 and the collagen I molecule affected in osteogenesis imperfecta

Research Opportunity
Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Prof Judy Savige jasavige@unimelb.edu.au 8344 3260 Personal web page

Summary The aim of this study is to develop interactome/protein binding maps of both these proteins. Skills acquired in the year include a critical review of the literature, and a greater understanding of structural biology and bioinformatics. These maps will be of great use to clinicians and will result in publications.

Project Details

BRCA1 is the gene affected in some cases of inherited breast cancer. This is a hub protein with more than300 binding partners. Many of these binding partners are also affected in other forms of inherited breast cancer. So the more binding partners we can find, the more we can contribute to the possible list of causes of breast cancer. Osteogenesis imperfecta is a rare disease characterised by bone fragility, and caused by mutations in the COL1A1 gene. Almost all mutations affect the Gly-X-Y sequence of the collagen molecule. In both diseases the pathogenicity of any mutation is related to whether the mutation affects the binding site of an important binding partner. Both these maps will be very helpful to clinicians in looking after patients.  The aim of this study is to develop interactome/protein binding maps of both these proteins.The BRCA1 map is partly completed.  Skills acquired in the year include a critical review of the literature, and a greater understanding of structural biology and bioinformatics. These maps will be of great use to clinicians and will result in publications.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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