Developing epigenetic biomarkers to predict pregnancy disorders and guide clinical practice.
- Research Opportunity
- PhD students, Masters by Research, Honours students, Master of Biomedical Science
- Number of Honour Places Available
- Number of Master Places Available
- Department / Centre
- Obstetrics and Gynaecology
- Royal Women’s Hospital
|Prof Eva Dimitriadisfirstname.lastname@example.org||03 83452215||Personal web page|
|Dr Ellen Menkhorstemail@example.com||Personal web page|
|Dr Wei Zhoufirstname.lastname@example.org||https://findanexpert.unimelb.edu.au/profile/842883-wei-zhou|
Summary Pregnancy complications such as preeclampsia, fetal growth restriction and pre-term birth affect up to 10% of all pregnancies. There is strong evidence that these complications are caused by abnormal placental development the during the 1st trimester, long before symptoms develop. Preeclampsia is a severe multi system disorder whereby the mother develops hypertension and proteinuria before 20 weeks of pregnancy. By this time, the placenta is damaged and releases factors into the mother’s blood leading to widespread endothelial cell damage and the symptoms of preeclampsia. Women can develop early onset, late onset and term preeclampsia, all of which can have severe consequences for both mother and baby not just during pregnancy but also later in life. Alarmingly there are no non-invasive tests that can predict all women who will develop preeclampsia and few treatment options. This project will use an experimental and bioinformatics approach to identify which women may develop preeclampsia and use primary human and organoid models to determine the functional significance of predictive biomarkers of disease. This may lead to developing a predictive test for preeclampsia and much needed personalised treatment options.
Faculty Research Themes
School Research Themes
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research NodeRoyal Women’s Hospital
MDHS Research library
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