Developing epigenetic biomarkers to predict pregnancy disorders and guide clinical practice.

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
Number of Master Places Available
Department / Centre
Obstetrics and Gynaecology
Royal Women’s Hospital
Primary Supervisor Email Number Webpage
Prof Eva Dimitriadis 03 83452215 Personal web page
Co-supervisor Email Number Webpage
Dr Ellen Menkhorst Personal web page
Dr Wei Zhou

Summary Pregnancy complications such as preeclampsia, fetal growth restriction and pre-term birth affect up to 10% of all pregnancies. There is strong evidence that these complications are caused by abnormal placental development the during the 1st trimester, long before symptoms develop. Preeclampsia is a severe multi system disorder whereby the mother develops hypertension and proteinuria before 20 weeks of pregnancy. By this time, the placenta is damaged and releases factors into the mother’s blood leading to widespread endothelial cell damage and the symptoms of preeclampsia. Women can develop early onset, late onset and term preeclampsia, all of which can have severe consequences for both mother and baby not just during pregnancy but also later in life. Alarmingly there are no non-invasive tests that can predict all women who will develop preeclampsia and few treatment options. This project will use an experimental and bioinformatics approach to identify which women may develop preeclampsia and use primary human and organoid models to determine the functional significance of predictive biomarkers of disease. This may lead to developing a predictive test for preeclampsia and much needed personalised treatment options.

Project Details

Faculty Research Themes

School Research Themes

Child Health in Medicine, Cardiometabolic , Women's Health

Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Obstetrics and Gynaecology

Research Node

Royal Women’s Hospital

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