Developing a human pre-cancer atlas of colonic polyps for predicting future risk of colorectal cancer or polyps
- Research Opportunity
- PhD, Masters by Research, Master of Biomedical Science
- Number of Honour Places Available
- Clinical Pathology
|Bernard Popefirstname.lastname@example.org||Personal web page|
|Daniel Buchananemail@example.com||0385597004||Personal web page|
The development of a colorectal cancer (CRC) is usually preceded by pre-cursor/pre-malignant lesion called a polyp. There are two major types of polyp defined by histological features namely the adenomatous polyp and the serrated polyp. It is now thought that both adenomatous polyps and a subset of serrated polyps are precursors to CRC. One in two Australians will develop at least one colorectal adenomatous polyp (adenomas) by 60 years of age, with, on average two adenomas detected per person. When an adenoma/serrated polyp is detected in the colon, it is generally removed by colonoscopic polypectomy and evaluated histologically. People with an adenoma are at a six-fold increased risk of developing a subsequent adenoma or CRC (metachronous neoplasia). We propose to build a human pre-cancer polyp atlas through comprehensive genomic, methylomic, transcriptomic and microbiome profiling to investigate mechanisms that predispose to and influence the development of pre-malignant polyps in the colon and that ultimately lead to their transformation to CRC. We hypothesize that this pre-cancer atlas will identify features associated with a high risk of metachronous colonic neoplasia. This project will develop expertise in molecular genetics/biology, histology, bioinformatic and statistical analysis. A stipend for this project is available to the selected student.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
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