Developing a human pre-cancer atlas of colonic polyps for predicting future risk of colorectal cancer or polyps

Research Opportunity
PhD, Masters by Research, Master of Biomedical Science
Number of Honour Places Available
1
Department
Clinical Pathology
Supervisor Email Number Webpage
Bernard Pope bjpope@unimelb.edu.au Personal web page
Daniel Buchanan daniel.buchanan@unimelb.edu.au 0385597004 Personal web page

Project Details

The development of a colorectal cancer (CRC) is usually preceded by pre-cursor/pre-malignant lesion called a polyp.  There are two major types of polyp defined by histological features namely the adenomatous polyp and the serrated polyp.  It is now thought that both adenomatous polyps and a subset of serrated polyps are precursors to CRC.  One in two Australians will develop at least one colorectal adenomatous polyp (adenomas) by 60 years of age, with, on average two adenomas detected per person.  When an adenoma/serrated polyp is detected in the colon, it is generally removed by colonoscopic polypectomy and evaluated histologically. People with an adenoma are at a six-fold increased risk of developing a subsequent adenoma or CRC (metachronous neoplasia).  We propose to build a human pre-cancer polyp atlas through comprehensive genomic, methylomic, transcriptomic and microbiome profiling to investigate mechanisms that predispose to and influence the development of pre-malignant polyps in the colon and that ultimately lead to their transformation to CRC.  We hypothesize that this pre-cancer atlas will identify features associated with a high risk of metachronous colonic neoplasia.  This project will develop expertise in molecular genetics/biology, histology, bioinformatic and statistical analysis.  A stipend for this project is available to the selected student.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Clinical Pathology


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