Determining the role of GM-CSF in osteoarthritis

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Associate Professor Andrew Cook adcook@unimelb.edu.au 83443290 Personal web page
Co-supervisor Email Number Webpage
Dr Ming-Chin Lee ming-chin.lee@unimelb.edu.au 83443292 Personal web page

Summary To determine the role of granulocyte macrophage-colony stimulating factor (GM-CSF) in osteoarthritis (OA) using experimental models the associated OA risk factor of obesity.

Project Details

Osteoarthritis (OA) is the most common form of arthritis, for which there are no adequate therapies. We have identified the inflammatory mediator, granulocyte macrophage-colony stimulating factor (GM-CSF) as important for the development of OA and its associated pain in animal models. Obesity is a major risk factor for OA development.

In this project you will use models of OA in association with obesity to determine the role of GM-CSF in pain and disease development associated with obesity and whether blockade of the pathway at different stages is able to halt disease progression. A variety of skills will be acquired including induction of animal models, histology, gene expression analysis and FACS analysis.



Faculty Research Themes

Infection and Immunology

School Research Themes

Musculoskeletal



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Hamilton Laboratory

Research Node

Royal Melbourne Hospital

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