Determining the role of GM-CSF in osteoarthritis
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- Number of Master Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Associate Professor Andrew Cookemail@example.com||83443290||Personal web page|
|Dr Ming-Chin Leefirstname.lastname@example.org||83443292||Personal web page|
Summary To determine the role of granulocyte macrophage-colony stimulating factor (GM-CSF) in osteoarthritis (OA) using experimental models the associated OA risk factor of obesity.
Osteoarthritis (OA) is the most common form of arthritis, for which there are no adequate therapies. We have identified the inflammatory mediator, granulocyte macrophage-colony stimulating factor (GM-CSF) as important for the development of OA and its associated pain in animal models. Obesity is a major risk factor for OA development.
In this project you will use models of OA in association with obesity to determine the role of GM-CSF in pain and disease development associated with obesity and whether blockade of the pathway at different stages is able to halt disease progression. A variety of skills will be acquired including induction of animal models, histology, gene expression analysis and FACS analysis.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research Group / Unit / Centre
Research NodeRoyal Melbourne Hospital
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