Determining the role of CCL17 in arthritis and inflammation
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|A/Prof Andrew Cookemail@example.com||8344 3290||Personal web page|
|Dr Ming-Chin Leefirstname.lastname@example.org||8344 3292||Personal web page|
Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting approximately 1% of the population. It results in destruction of joints, with pain being a major symptom. We have shown that CCL17 is important for the development of several models of inflammation and arthritis, in particular the development of pain. Blockade of CCL17 is effective at reversing the pain and reducing arthritis severity. However, we still do not completely understand how CCL17 is acting during inflammation and arthritis.
In this project you will study the role of CCL17 in inflammation and arthritis, including in the development of pain. Techniques to be used include induction of animal models of human disease, measurement of inflammatory mediator gene expression by real time-PCR and protein by ELISA, and the use of FACS and immunohistochemistry to study cell populations.
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research Group / Unit / Centre
Research NodeRoyal Melbourne Hospital
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