Determinging the role of CCL17 in arthritis and inflammation

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Ming-Chin Lee ming-chin.lee@unimelb.edu.au 8344 3292 Personal web page
Andrew Cook adcook@unimelb.edu.au 8344 3290 Personal web page

Project Details

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting approximately 1% of the population. It results in destruction of joints, with pain being a major symptom. We have shown that CCL17 is important for the development of several models of inflammation and arthritis, in particular the development of pain. Blockade of CCL17 is effective at reversing the pain and reducing arthritis severity. However, we still do not completely understand how CCL17 is acting during inflammation and arthritis.

In this project you will study the role of CCL17 in inflammation and arthritis, including in the development of pain. Techniques to be used include induction of animal models of human disease, measurement of inflammatory mediator gene expression by real time-PCR and protein by ELISA, and the use of FACS and immunohistochemistry to study cell populations.


School Research Themes

Musculoskeletal



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Hamilton Laboratory

Research Node

Royal Melbourne Hospital

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