Defining the role of p53 in cancer immunotherapy

Research Opportunity
PhD, Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Primary Supervisor Email Number Webpage
Prof Ygal Haupt ygal.haupt@petermac.org +613 8559 7102
Co-supervisor Email Number Webpage
Dr Sue Haupt sue.haupt@petermac.org +613 8559 6477

Project Details

Despite clear evidence of an association between the tumour suppressor p53 and immunity, a gap in knowledge exists regarding its role in modulating immune responses, or its value in predicting patient responses to immunotherapy. Given the unprecedented frequency of p53 mutation in cancers and the heterogeneous responses to immunotherapy, this question deserves rigorous exploration.

P53 activity has been associated with tumour-infiltration and immune activation. Despite the prevalence of p53 mutations in human cancers (>50%) and its link to immune regulation, the impact of p53 status on the immune response, and on the response to immune checkpoint inhibitors has not been explored. These fundamental questions, which potentially affect many cancer types and a large proportion of cancer patients, form the basis of this study.

The project will involve work with cancer cell lines, transgenic mouse models, and human samples. In addition the project will expose students to a variety of molecular, cellular biochemical techniques, immune profiling, and to genomic and bioinformatics analyses.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology


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