Context-induced relapse to alcohol-seeking after voluntary abstinence
- Research Opportunity
- PhD, Masters by Research, Honours
- Number of Honour Places Available
- Medicine and Radiology
- Florey Institute of Neuroscience & Mental Health
|Andrew Lawrence||Andrew.Lawrence@florey.edu.au||90356692||Personal web page|
Substance abuse is a major health care problem. Accordingly, there is a real need to increase our fundamental understanding of the processes behind addiction, so that more targeted therapeutic strategies can follow. We have identified a potentially critical neural mechanism by which alcohol associated environments promote alcohol seeking during abstinence. We will further unravel the brain mechanisms of relapse to alcohol seeking, and will identify novel brain areas and circuits that future clinical studies can target in treatment-seeking alcoholics.
A limitation identified in animal models is that abstinence is achieved ‘non-voluntarily’ (experimenter-imposed). In humans, however, abstinence is typically voluntary (self-imposed), despite drug availability and often out of a desire to avoid the negative consequence associated with excessive alcohol use. A recently developed animal model addresses this limitation. In this model, the laboratory animal abstains voluntarily from alcohol use when alcohol-seeking is associated with a negative consequence. We will combine this novel animal model of relapse with innovative procedures to manipulate neurons in defined neural circuits to determine which circuitry is critical for context-induced relapse to alcohol seeking.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeFlorey Institute of Neuroscience & Mental Health
MDHS Research library
Explore by researcher, school, project or topic.