Characterising the immune response to RSV in preterm and term infants

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Associate Professor Paul Licciardi paul.licciardi@mcri.edu.au Personal web page
Co-supervisor Email Number Webpage
Doctor Lien Anh Ha Do lienanhha.do@mcri.edu.au

Summary Using a cohort of preterm and term infant cord blood samples, we aim to characterise their immune response profiles by using a combination of cell culture, flow cytometry and multiplex cytokine assays. This data will provide important insights into the immunological susceptibility to severe RSV during early life with the promise of developing more targeted approaches to protect this vulnerable group of infants.

Project Details

Respiratory syncytial virus (RSV) is the most common viral pathogen associated with acute lower respiratory tract infection in children. Globally, RSV affects 33 million children and causes 60,000 in-hospital deaths in children under 5 years of age each year, with severe infection more likely to occur in preterm infants. The increased susceptibility to RSV among preterm infants is thought to be due to immaturity of the immune system. Using a cohort of preterm and term infant cord blood samples, we aim to characterise their immune response profiles by using a combination of cell culture, flow cytometry and multiplex cytokine assays. This data will provide important insights into the immunological susceptibility to severe RSV during early life with the promise of developing more targeted approaches to protect this vulnerable group of infants.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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