Cellular and Molecular Mechanisms Driving Anthracycline-Induced Cardiotoxicity in Children

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science, Post Doctor Researchers
Number of Honour Places Available
2
Number of Master Places Available
2
Department / Centre
Baker Department of Cardiometabolic Health
Location
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Dr Alexander Pinto alex.pinto@baker.edu.au 85321111 Personal web page
Co-supervisor Email Number Webpage
Dr Malathi Dona malathi.imiyagedona@baker.edu.au 85321111 Personal web page

Summary Anthracyclines such as doxorubicin are effective chemotherapeutic agents for treating childhood cancers with a survival rate of 84% in Australia . More recently however, it has been reported that survivors treated with doxorubicin during childhood risk a 6-10 fold increased incidence of developing early onset heart failure. By applying advanced genetic, flow cytometric, imaging and single cell transcriptomic approaches, the aim of this project is to determine the impact of doxorubicin on the cardiac cellular landscape and the development of pathological cardiac remodelling. Specifically, this project will test the hypothesis that doxorubicin age- and sex-specifically remodels the cardiac cellular landscape.



Faculty Research Themes

School Research Themes

Cancer in Medicine, Ageing, Cardiometabolic



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science, Post Doctor Researchers
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

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