Cancer drug discovery by inhibition of a DNA repair pathway

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Project Status
Medicine and Radiology
St Vincent's Hospital
Supervisor Email Number Webpage
Dr Wayne Crismani Personal web page

Project Details

Want to cure cancer? We do too. Join our dynamic young team of experts, in the identification and characterisation of new potential cancer therapeutics. In this project, you would also learn about DNA repair, genetic diseases and a variety of laboratory-based techniques (AlphaScreen drug discovery assays, recombinant DNA technology, CRISPR gene targeting, drug discovery, cell-based chemotherapy response assays, pharmacokinetics, protein purification and in vitro enzyme assays).

Chemotherapy is one of the essential tools in modern cancer treatment. Chemotherapy works by creating DNA damage in cancer cells, but tumour cells can gain resistance by upregulating DNA repair pathways. Our team has made major breakthroughs in reconstituting these DNA repair reactions in vitro, allowing a new approach to design of DNA repair inhibiting drugs. This approach may identify sensitisers that would make these “untreatable” cancers receptive to traditional chemotherapies. By joining us you will gain exposure to basic and translational research that is at the forefront internationally. You will receive training in a molecular biology laboratory with a focus on biochemistry and cell biology, increase your understanding of cancer biology and treatment, and increase your employability particular in the science sector.

This project is conducted in St Vincent’s Institute of Medical Research, Genome Stability Unit.

Faculty Research Themes


School Research Themes

Cancer in Medicine

Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Graduate Research Students who are interested in joining this project will need to consider their elegibility as well as other Graduate Research requirements before contacting the supervisor of this research

View application process

Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Node

St Vincent's Hospital

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