Can we Fix Dementia with Deep Brain Stimulation?

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Chris French frenchc@unimelb.edu.au 8344 3276 Personal web page

Project Details

"Lewy Body Dementia" is the second most common form of dementia after Alzheimer's disease, but we don't understand how it damages patients' ability to think and function. We suspect that part of the problem is that the brain goes "out of sync" like a misfiring engine, that is, has problems of signal timing. In an animal model, we want to see if we can detect signs of damaged brain signal synchronization, and see if we can improve or fix this either with drugs or a kind of "brain pacemaker". If we can show these treatments work in the animal model, it could lead to major improvements in therapies for these patients.

Deep brain stimulation is incredibly effective for some neurodegenerative conditions such as Parkinson’s disease. Despite the success of this technique, little is actually known about how it works. The first half of this project involves implanting stimulation electrodes into the brains of mice, and looking for the changes in neuron firing as well as brain rhythms that result from stimulating particular areas of the brain. The second part is to see if the performance of animals with impaired cognition can be improved with brain stimulation. Check out https://ndl-lab.org/home



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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