Building a Tumourigenesis Atlas for Lynch syndrome related-colorectal cancer

Research Opportunity
PhD, Masters by Research, Master of Biomedical Science
Number of Honour Places Available
1
Department
Clinical Pathology
Primary Supervisor Email Number Webpage
A/Prof Daniel Buchanan daniel.buchanan@unimelb.edu.au 0385597004 Personal web page

Project Details

Lynch syndrome is one of the most common hereditary cancer syndromes caused by autosomal dominant inheritance of germline mutations in one of the DNA mismatch repair (MMR) genes, MLH1, MSH2, MSH6 or PMS2.  Mutation carriers are at a significantly increased risk of colorectal cancer (CRC).  Recent studies hypothesize the existence of multiple pathways of tumourigenesis which is thought to underlie the molecular heterogeneity of CRCs in Lynch syndrome, however, this is yet to be validated.  The aim of this project is to build the first a tumorigenesis atlas for Lynch syndrome encompassing normal colonic mucosa, adenoma and carcinoma tissue to elucidate the pathways of tumorigenesis and the molecular features associated with CRC development, including for interval and metachronous CRCs.  The project will involve genomic, epigenomic, microbiome and immune profiling of pre-malignant and malignant tissue from individuals with Lynch syndrome to identify the key molecular features of CRC initiation and progression.  This project will develop expertise in molecular genetics/biology, histology, bioinformatics and statistical analysis.  The outcomes of this project will have significant international impact through the development of a novel tumourigenesis atlas for Lynch syndrome related-colorectal cancer.  A stipend for this project is available to the selected student.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Clinical Pathology


MDHS Research library
Explore by researcher, school, project or topic.