Biophenotypes for Personalised Psychiatry

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
2
Department
Psychiatry
Group Leader Email Number Webpage
Prof. Bernhard Baune bbaune@unimelb.edu.au

Project Details

Current diagnostic categories in mental illness are based largely on common symptomatology rather than an understanding of the underlying mechanisms of brain, cognitive and general day-to-day function. Illness and functional trajectories describe patterns of illness and impairment in individuals over time. This research group will apply probabilistic and growth mixture multivariate modelling techniques to various measures of patient history to identify and predict specific illness and functional trajectories in mood and psychotic disorders.

Prediction of outcomes and treatment response in chronic psychosis 

This study uses multimodal clinical and blood based biomarker data to predict medication response, cognition and outcomes in chronic psychosis with novel Bayesian and Machine Learning and trajectory Modelling techniques in a large samples of patients treated with depot antipsychotics or clozapine.

Prediction of outcomes and treatment response in mood disorders 

This study uses multimodal clinical and blood based biomarker data to predict medication response, cognition and outcomes in chronic psychosis with novel Bayesian and Machine Learning and trajectory modelling techniques in a large sample of patients treated and has a specific focus on response to antidepressants in depression and to lithium in bipolar disorder.

Polygenic risk score prediction of psychiatric phenotypes

This study investigates the genetic prediction of clinically relevant phenotypes in depression including emotions processing, cognitive functioning and psychosocial functioning. Students will learn to create such polygenic risk scores and will analyses these in conjunction with the available data in depression.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Psychiatry


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