Biofabrication of an in vitro 3D osteosarcoma model

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Surgery
Location
St Vincent's Hospital
Group Leader Email Number Webpage
A/Prof Claudia di Bella claudia.dibella@unimelb.edu.au Personal web page
Primary Supervisor Email Number Webpage
Dr Serena Duchi serena.duchi@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Carmine Onofrillo carmine.onofrillo@unimelb.edu.au Personal web page
Prof Peter Choong pchoong@unimelb.edu.au Personal web page

Summary The goal of this project is to generate a 3D in vitro model of osteosarcoma using primary tumour cells and 3D bioprinting technologies.

Project Details

Osteosarcoma (OS) is a rare and highly aggressive bone cancer, with poor prognosis. Unfortunately, current in vitro preclinical models such as monolayer cell culture, fail to recapitulate the Tumour MicroEnvironment (TME) and thus accurate neoplastic behaviour, ultimately hindering therapeutic discovery. The employment of Three-Dimensional OS cell culture Models (3D-OSM) has the potential to better recreate the spatial, mechanical, and biological complexity of the TME, key elements crucial for understanding tumour prognosis and treatment effectiveness.

The goal of this project is to generate a 3D in vitro model of osteosarcoma using primary tumour cells and 3D bioprinting technologies. This project will train the candidate in tumour cells culturing, molecular and immunostaining analysis, 3D bioprinting, material science, fluorescence microscopy, microCT imaging.

This project is suited for a Honor/Master/PhD research project.

The experimental work for this project will be conducted at the 3DBioFab@ACMD, St.Vincent’s Hospital, Melbourne.


School Research Themes

Musculoskeletal



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Surgery

Research Group / Unit / Centre

Advanced Limb Reconstruction

Research Node

St Vincent's Hospital

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