Biofabrication of an in vitro 3D osteosarcoma model
- Research Opportunity
- PhD students, Masters by Research
- Department / Centre
- St Vincent's Hospital
|A/Prof Claudia di Bellaemail@example.com||Personal web page|
|Dr Serena Duchifirstname.lastname@example.org||Personal web page|
|Dr Carmine Onofrilloemail@example.com||Personal web page|
|Prof Peter Choongfirstname.lastname@example.org||Personal web page|
Summary The goal of this project is to generate a 3D in vitro model of osteosarcoma using primary tumour cells and 3D bioprinting technologies.
Osteosarcoma (OS) is a rare and highly aggressive bone cancer, with poor prognosis. Unfortunately, current in vitro preclinical models such as monolayer cell culture, fail to recapitulate the Tumour MicroEnvironment (TME) and thus accurate neoplastic behaviour, ultimately hindering therapeutic discovery. The employment of Three-Dimensional OS cell culture Models (3D-OSM) has the potential to better recreate the spatial, mechanical, and biological complexity of the TME, key elements crucial for understanding tumour prognosis and treatment effectiveness.
The goal of this project is to generate a 3D in vitro model of osteosarcoma using primary tumour cells and 3D bioprinting technologies. This project will train the candidate in tumour cells culturing, molecular and immunostaining analysis, 3D bioprinting, material science, fluorescence microscopy, microCT imaging.
This project is suited for a Honor/Master/PhD research project.
The experimental work for this project will be conducted at the 3DBioFab@ACMD, St.Vincent’s Hospital, Melbourne.
School Research Themes
PhD students, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Research NodeSt Vincent's Hospital
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