Arterial coronary artery bypass surgery

Research Opportunity
PhD
Number of Honour Places Available
1
Department
Surgery
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Colin Royse Colin.Royse@unimelb.edu.au +61408567548 Personal web page
Alistair Royse Alistair.Royse@unimelb.edu.au +61418554135 Personal web page

Project Details

95% of coronary bypass surgery is performed using at least one saphenous vein graft (SVG) from the leg. Yet this conduit is a vein and not an artery, and is subject to progressive failure over time due to the development of progressive and accelerated atherosclerosis. This leads to recurrence of angina, myocardial infarction and heart failure; each of which may contribute to higher mortality.

At the Royal Melbourne Hospital (RMH), "total arterial revascularisation" has been practice in at least 85% of patients since 1996 with individual surgeons as high as 99.7%. Recent large scale analyses from the Australian dataset of more than 51,000 patients, demonstrate a survival disadvantage to the use of  SVG. Indeed, in sub-analyses, even one single SVG leads to worse survival over time.

The alternative arterial conduit, radial artery (RA) was pioneered at RMH, and has one of the largest experiences in the world. This contributes reliably, to the achievement of total arterial revascularisation. There remains a considerable dataset that may be analysed and is most suitable for a PhD. It is expected that publications arising from this body of work will continue to be published in the highest impact journals.


School Research Themes

Cardiometabolic



Research Opportunities

PhD
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

Royal Melbourne Hospital

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