Applying New Genomic Technologies To Understand The Genetic Basis Of Autism Spectrum Disorder
- Research Opportunity
- Royal Children’s Hospital/Murdoch Childrens Research Institute
|Associate Professor Paul Lockhartemail@example.com||+61383416322||Personal web page|
|Dr Kiymet Bozaoglufirstname.lastname@example.org||Personal web page|
Autism Spectrum Disorder (ASD) is a complex and highly heritable neurodevelopmental disorder defined by deficits in social communication and repetitive behaviours with restricted interests. Over 300,000 Australians have ASD and the annual national economic cost is ~$9.7 billion. ASD typically display complex inheritance but the genetic basis underpinning the disease remains largely unexplained. This project aims to understand the genetic basis of ASD by performing genetic studies in large families with 2 or more affected children. Novel genes will be characterised to understand pathogenic mechanisms underlying disease utilising advanced molecular and cell biology techniques. Subsequent studies will utilise newly developed and unique iPSC models to perform preclinical studies to characterise the disease process and identify potential therapeutic targets. This project is multidisciplinary and involves close collaborations with clinical researchers and bioinformaticians. The outcomes will enable understanding of the molecular basis of ASD and identify potential therapeutic targets for clinical management.
Faculty Research Themes
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Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
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Research NodeRoyal Children’s Hospital/Murdoch Childrens Research Institute
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