Animal models of Brain Development assessed using histology

Research Opportunity
PhD students, Masters by Research, Master of Biomedical Science
Department
Psychiatry
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Professor Christos Pantelis cpant@unimelb.edu.au
Co-supervisor Email Number Webpage
Dr Liliana Laskaris lily.laskaris@unimelb.edu.au 0447622391

Summary Cognitive and memory deficits underlie and, in some cases, precede the diagnosis of many neuropsychiatric disorders from depression to autism and schizophrenia. The hippocampus is a key brain region responsible for cognitive and memory processing. The aim of the current project is to model hippocampal functioning in the mouse brain using a combination of histological and biochemical techniques, and to determine whether differences are present between age groups.

Project Details

Clinical neuro-imaging research conducted at the Melbourne Neuropsychiatry Centre (MNC) has led to the development of novel animal models examining neurodevelopment and maturation of both behaviour and cognition. A newly commenced Program Grant aims to map brain-structure-function relationships and molecular signatures across developmental stages in the mouse, as measured through novel neuroimaging techniques and microscopy. 

Cognitive and memory deficits underlie and, in some cases, precede the diagnosis of many neuropsychiatric disorders from depression to autism and schizophrenia. The hippocampus is a key brain region responsible for cognitive and memory processing. The aim of the current project is to model hippocampal functioning in the mouse brain using a combination of histological and biochemical techniques, and to determine whether differences are present between age groups. It is expected that this research will be a first step in a larger set of studies aiming to integrate behavioural, cognitive and clinical information across both humans and animal studies.

The student will be responsible for conducting a literature review of the area, the development of the proposal and generation of specific study hypotheses, as well as conducting immunohistochemistry in neuronal and glial cells in the hippocampus with particular focus on synapses and the quantification of neurotransmitters in this region.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD students, Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Psychiatry

Research Node

Royal Melbourne Hospital

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