An antibody (mAb2E1) that detects a novel, high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells, developing brain and bone, and an osteosarcoma cell line
- Research Opportunity
- PhD students
- Department / Centre
- Medicine
- Location
- Austin Health
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Peter J Wookey | pwookey@unimelb.edu.au | +3 9496 3584 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Prof David Hare | Personal web page |
Summary An antibody was developed that binds high molecular weight targets (HMWT) with similar properties to the natural ligands of the calcitonin receptor (CTR).
Project Details
A similar HMWT has recently been described as a surrogate ligand of CTR that promotes quiescence of skeletal muscle satellite (stem) cells via activation of the NOTCH-COLLAGEN V-CTR axis. The detected HMWTs are found expressed by malignant cells of brain tumours and cell lines. The biochemical identification of this HMWT is a current objective. Understanding the role of this HMWT is likely to contribute to our understanding of endocrine-like tumours and foetal development.
Faculty Research Themes
School Research Themes
Cancer in Medicine, Cardiometabolic , Neuroscience & Psychiatry
Research Opportunities
PhD students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Research Node
Austin HealthMDHS Research library
Explore by researcher, school, project or topic.