An antibody that detects a high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells and cell lines

Research Opportunity
PhD, Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Austin Health
Primary Supervisor Email Number Webpage
Dr Peter Wookey pwookey@unimelb.edu.au +3 9496 3584 Personal web page
Co-supervisor Email Number Webpage
Prof David Hare Personal web page

Summary An antibody was developed that binds high molecular weight targets (HMWT) with similar properties to the natural ligands of the calcitonin receptor (CTR).

Project Details

A similar HMWT has recently been described as a surrogate ligand of CTR that promotes quiescence of skeletal muscle satellite (stem) cells via activation of the NOTCH-COLLAGEN V-CTR axis. The detected HMWTs are found expressed by malignant cells of brain tumours and cell lines. The biochemical identification of this HMWT is a current objective. Understanding the role of this HMWT is likely to contribute to our understanding of endocrine-like tumours and foetal development.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine, Cardiometabolic , Neuroscience & Psychiatry



Research Opportunities

PhD, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Cardiovascular and Tumourivascular Laboratory

Research Node

Austin Health

MDHS Research library
Explore by researcher, school, project or topic.