An antibody (mAb2E1) that detects a novel, high molecular weight surrogate ligand of calcitonin receptor is detected in malignant glioma cells, developing brain and bone, and an osteosarcoma cell line
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- PhD students
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- Austin Health
|Dr Peter J Wookeyemail@example.com||+3 9496 3584||Personal web page|
|Prof David Hare||Personal web page|
Summary An antibody was developed that binds high molecular weight targets (HMWT) with similar properties to the natural ligands of the calcitonin receptor (CTR).
A similar HMWT has recently been described as a surrogate ligand of CTR that promotes quiescence of skeletal muscle satellite (stem) cells via activation of the NOTCH-COLLAGEN V-CTR axis. The detected HMWTs are found expressed by malignant cells of brain tumours and cell lines. The biochemical identification of this HMWT is a current objective. Understanding the role of this HMWT is likely to contribute to our understanding of endocrine-like tumours and foetal development.
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