An anti-calcitonin receptor (CTR) antibody for the detection of programmed cell death: the role of CTR in a novel adaptive response in a pre-apoptotic mechanism
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- PhD students
- Department / Centre
- Austin Health
|Dr Peter Wookeyfirstname.lastname@example.org||0419 633 146||Personal web page|
Summary Programmed cell death (PCD) is an essential process in life.
Programmed cell death (PCD) is an essential process in life. For apoptosis the sequelae of events resulting in PCD, include mitochondrial changes, exposure of phosphatidylserine, activation of caspases, etc.. Another key pathway is autophagy, initially a response to cell stress. We have found evidence of expression of CTR during the pre-apoptotic cell stress response. There are two common isoforms of human calcitonin receptor (CTR) which differ by an extra 16-amino acid insert in CTRb. We are exploring a role in pre-apoptotic cell stress, apoptosis and autophagy using unique antibodies developed here, including one antibody that binds the insert sequence.
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