An anti-calcitonin receptor (CTR) antibody for the detection of programmed cell death: the role of CTR in a novel adaptive response in a pre-apoptotic mechanism
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- Medicine and Radiology
- Austin Health
|Dr Peter Wookeyemail@example.com||Personal web page|
Programmed cell death (PCD) is an essential process in life. For apoptosis the sequelae of events resulting in capitulation and PCD, include changes in mitochondrial membrane potential, shunting of phosphatidylserine to the cell surface, activation of caspases, chromatin condensation and DNA fragmentation, amongst other key molecular events. Another key pathway activated in PCD is autophagy, initially a response to cell stress. We have found evidence of expression of CTR during the pre-apoptotic cell stress response . There are two common isoforms of human calcitonin receptor (CTR) which differ by an extra 16-amino acid insert in CTRb. While the pharmacology of CTRa (insert-negative) has been well established , little is known about the physiological role of CTRb (insert-positive) in cells. We are exploring a role in pre-apoptotic cell stress using unique antibodies developed here, including one antibody that binds the insert sequence.
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