An anti-calcitonin receptor (CTR) antibody for the detection of programmed cell death: the role of CTR in a novel adaptive response in a pre-apoptotic mechanism

Research Opportunity
Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Austin Health
Primary Supervisor Email Number Webpage
Dr Peter Wookey pwookey@unimelb.edu.au Personal web page

Project Details

Programmed cell death (PCD) is an essential process in life. For apoptosis the sequelae of events resulting in capitulation and PCD, include changes in mitochondrial membrane potential, shunting of phosphatidylserine to the cell surface, activation of caspases, chromatin condensation and DNA fragmentation, amongst other key molecular events. Another key pathway activated in PCD is autophagy, initially a response to cell stress. We have found evidence of expression of CTR during the pre-apoptotic cell stress response [4]. There are two common isoforms of human calcitonin receptor (CTR) which differ by an extra 16-amino acid insert in CTRb. While the pharmacology of CTRa (insert-negative) has been well established [5], little is known about the physiological role of CTRb (insert-positive) in cells. We are exploring a role in pre-apoptotic cell stress using unique antibodies developed here, including one antibody that binds the insert sequence.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine, Cardiometabolic



Research Opportunities

Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Cardiovascular and Tumourivascular Laboratory

Research Node

Austin Health

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