Altered functional and phenotypic characteristics following treatment of age-related macular degeneration
- Research Opportunity
- Honours, Master of Biomedical Science
- Number of Honour Places Available
- Medicine and Radiology
- Florey Institute of Neuroscience & Mental Health
|James S. Wileyemail@example.com||03834463856||Personal web page|
|Ben J. Gufirstname.lastname@example.org||+61390356317||Personal web page|
Age-related macular degeneration (AMD) is a multifactorial disease and is a leading cause of irreversible vision loss in Australia. AMD at its early stage is characterized by accumulation of debris (lipid rich drusen) in retina, which is believed due to reduced clearance capacity. Certain treatment may stimulate the release of chemoattractant cytokines and allow accumulation of monocytes from peripheral blood to migrate into retina. Such stimulation may also promote the expression of scavenger receptors on monocyte surface and increase phagocytic ability of these cells, which would facilitate the clearance of accumulated debris in retina (druse and pseudodrusen). In this study, we will measure the phagocytosis ability of monocytes and monocyte subsets from AMD patients before and after treatment, using a real-time tri-colour flow cytometry method developed by our group. Leukocyte phenotyping, membrane fluidity and cytokine release will also be studied. This study will not only identify a useful pattern for assessment of treatment efficacy and prediction of outcome, but also provide insights on the pathogenesis and development of this disease.
Faculty Research Themes
School Research Themes
Honours, Master of Biomedical Science
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Research NodeFlorey Institute of Neuroscience & Mental Health
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