Altered functional and phenotypic characteristics following treatment of age-related macular degeneration

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Florey Institute of Neuroscience & Mental Health
Supervisor Email Number Webpage
James S. Wiley james.wiley@florey.edu.au 03834463856 Personal web page
Ben J. Gu ben.gu@florey.edu.au +61390356317 Personal web page

Project Details

Age-related macular degeneration (AMD) is a multifactorial disease and is a leading cause of irreversible vision loss in Australia. AMD at its early stage is characterized by accumulation of debris (lipid rich drusen) in retina, which is believed due to reduced clearance capacity. Certain treatment may stimulate the release of chemoattractant cytokines and allow accumulation of monocytes from peripheral blood to migrate into retina.  Such stimulation may also promote the expression of scavenger receptors on monocyte surface and increase phagocytic ability of these cells, which would facilitate the clearance of accumulated debris in retina (druse and pseudodrusen). In this study, we will measure the phagocytosis ability of monocytes and monocyte subsets from AMD patients before and after treatment, using a real-time tri-colour flow cytometry method developed by our group. Leukocyte phenotyping, membrane fluidity and cytokine release will also be studied. This study will not only identify a useful pattern for assessment of treatment efficacy and prediction of outcome, but also provide insights on the pathogenesis and development of this disease.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry, Ageing



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Florey Institute of Neuroscience & Mental Health

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