Alcohol and striatal adaptation

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Florey Institute of Neuroscience & Mental Health
Supervisor Email Number Webpage
Leigh Walker leigh.walker@florey.edu.au
Andrew Lawrence Andrew.Lawrence@florey.edu.au 90356692 Personal web page

Project Details

Project description: Despite the major socioeconomic burden, alcohol use disorders (AUDs) remain a major health risk, and current medications are still inadequate to treat both relapse and heavy drinking. Our lab has recently shown muscarinic acetylcholine receptors (mAChR) undergo adaptations following chronic alcohol consumption in both humans and rodent brains. Further, using selective compounds we have recently confirmed the functional relevance of M4 and M5 muscarinic receptors in regulating voluntary alcohol intake in rodents.

Therefore in this novel and innovative study we aim to:

1. characterise the molecular and electrophysiological consequences of chronic intermittent alcohol intake on cholinergic transmission in the rat striatum.

2. examine in rats how brain region specific pharmacological manipulation of M4 or M5 muscarinic receptors impacts upon alcohol use / relapse.

This project will utilise a range of molecular and behavioural techniques including operant self-administration, rodent surgery, electrophysiology, qPCR, microscopy and immunohistochemistry.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Florey Institute of Neuroscience & Mental Health

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