Alcohol and striatal adaptation
- Research Opportunity
- PhD, Masters by Research, Honours
- Number of Honour Places Available
- Medicine and Radiology
- Florey Institute of Neuroscience & Mental Health
|Andrew Lawrence||Andrew.Lawrence@florey.edu.au||90356692||Personal web page|
Project description: Despite the major socioeconomic burden, alcohol use disorders (AUDs) remain a major health risk, and current medications are still inadequate to treat both relapse and heavy drinking. Our lab has recently shown muscarinic acetylcholine receptors (mAChR) undergo adaptations following chronic alcohol consumption in both humans and rodent brains. Further, using selective compounds we have recently confirmed the functional relevance of M4 and M5 muscarinic receptors in regulating voluntary alcohol intake in rodents.
Therefore in this novel and innovative study we aim to:
1. characterise the molecular and electrophysiological consequences of chronic intermittent alcohol intake on cholinergic transmission in the rat striatum.
2. examine in rats how brain region specific pharmacological manipulation of M4 or M5 muscarinic receptors impacts upon alcohol use / relapse.
This project will utilise a range of molecular and behavioural techniques including operant self-administration, rodent surgery, electrophysiology, qPCR, microscopy and immunohistochemistry.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeFlorey Institute of Neuroscience & Mental Health
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