Advancing vaccine development for infectious diseases: bioinformatics, antibody engineering, immunoassay development and human cohort studies

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
2
Department
Medicine and Radiology
Location
Burnet Institute
Primary Supervisor Email Number Webpage
Dr Jack Richards Jack.Richards@burnet.edu.au +61 3 9282 2111 Personal web page
Co-supervisor Email Number Webpage
Dr Ricardo Ataide Ricardo.Ataide@burnet.edu.au +61 3 9282 2111

Project Details

Infectious diseases continue to be a major burden on global health. They contribute to global inequities, especially in low-middle income countries and to the world's most disadvantaged people. Some of these are well recognised diseases like malaria, TB, HIV, dengue, and viral hepatitis, but others are new and emerging threats. For many of these diseases, antibodies are key effector molecules responsible for mediating protection. This project will provide opportunities to study the fascinating biology of these diseases and to understand more about immune responses against them. It will use a range of novel approaches (i.e. combinations of bioinformatics, proteomics, and immunology) to identify epitopes that are targeted by protective antibodies. There will be opportunities to engineer new recombinant human antibodies and then test these in a wide range of in vitro assays and in vivo models. This will provide crucial insights into the mechanisms that mediate protection and to identify which of these are most effective. This knowledge will then be used to guide vaccine construct design, adjuvant selection and assessing vaccine delivery strategies to ensure that these responses can be induced and maintained. These projects can be tailored to specific student interests.



Faculty Research Themes

Infection and Immunology

School Research Themes

Child Health in Medicine, Women's Health



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Burnet Institute

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