Adipocytes as Weapons of Bone Destruction: The bone as a War Zone
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Number of Honour Places Available
- Number of Master Places Available
- Department / Centre
- Medicine and Radiology
- Western Health
|Professor Gustavo Duquefirstname.lastname@example.org||Personal web page|
|Dr. Ahmed Al Seadiemail@example.com||Personal web page|
Summary Osteoporosis in older persons is the consequence of predominant differentiation of mesenchymal stem cells (MSC) into fat at the expense of osteoblastogenesis and bone formation.
We have obtained strong evidence that increasing marrow fat is toxic to bone cells and create an unfriendly bone marrow milieu. However, the mechanisms explaining this lipotoxic effect remain to be elucidated. In addition, the specific biological and metabolic characteristics of marrow fat remain unknown. These projects are aimed to characterise marrow adipocytes, determine their differences versus other types of fat, elucidate the mechanisms of lipotoxicity in bone, and develop new therapies to protect bone cells from lipotoxicity.
School Research Themes
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
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Department / Centre
Research NodeWestern Health
MDHS Research library
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