Adipocytes as Weapons of Bone Destruction: The bone as a War Zone

Research Opportunity
PhD students, Masters by Research, Honours students
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Western Health
Primary Supervisor Email Number Webpage
Professor Gustavo Duque gustavo.duque@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr. Ahmed Al Seadi ahmed.mohan@unimelb.edu.au Personal web page

Summary Osteoporosis in older persons is the consequence of predominant differentiation of mesenchymal stem cells (MSC) into fat at the expense of osteoblastogenesis and bone formation.

Project Details

We have obtained strong evidence that increasing marrow fat is toxic to bone cells and create an unfriendly bone marrow milieu. However, the mechanisms explaining this lipotoxic effect remain to be elucidated. In addition, the specific biological and metabolic characteristics of marrow fat remain unknown. These projects are aimed to characterise marrow adipocytes, determine their differences versus other types of fat, elucidate the mechanisms of lipotoxicity in bone, and develop new therapies to protect bone cells from lipotoxicity.


School Research Themes

Ageing, Musculoskeletal



Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Western Health

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