Adipocytes as Weapons of Bone Destruction: The bone as a War Zone
- Research Opportunity
- PhD students, Masters by Research
- Department / Centre
- Medicine
- Location
- Western Health
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Gustavo Duque | gustavo.duque@unimelb.edu.au | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr. Ahmed Al Seadi | ahmed.mohan@unimelb.edu.au | Personal web page |
Summary Osteoporosis in older persons is the consequence of predominant differentiation of mesenchymal stem cells (MSC) into fat at the expense of osteoblastogenesis and bone formation.
Project Details
We have obtained strong evidence that increasing marrow fat is toxic to bone cells and create an unfriendly bone marrow milieu. However, the mechanisms explaining this lipotoxic effect remain to be elucidated. In addition, the specific biological and metabolic characteristics of marrow fat remain unknown. These projects are aimed to characterise marrow adipocytes, determine their differences versus other types of fat, elucidate the mechanisms of lipotoxicity in bone, and develop new therapies to protect bone cells from lipotoxicity.
School Research Themes
Research Opportunities
PhD students, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Node
Western HealthMDHS Research library
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