Acquired epilepsy in Alzheimer’s disease

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Jianxiong Chan jianxiong.chan@unimelb.edu.au Personal web page
Patrick Kwan patrick.kwan@unimelb.edu.au

Project Details

Alzheimer's disease (AD) patients are 10 times more likely to develop epilepsy compared with age-matched controls. The treatment of recurrent seizures with conventional antiepileptic drugs may exacerbate cognitive decline. There are currently no treatments that prevent epilepsy in AD patients and the pathological basis for the increased risk of epilepsy is largely unknown Understanding the pathomechanisms of epileptogenesis in AD is crucial in identifying effective therapeutic strategies. This will help to prevent the development of epilepsy in this high risk and vulnerable population. This project aims to directly address the mechanisms of epileptogenesis in AD through the study of animal models of AD and acquired epilepsy. The aims will be achieved by subjecting transgenic AD models reflecting the pathological hallmarks to acquired epileptogenesis and treating them novel compounds. The phenotypic changes will be correlated with the molecular and cellular changes in these pathways.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Epilepsy and Precision Medicine

Research Node

Royal Melbourne Hospital

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