Acquired epilepsy in Alzheimer’s disease
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Jianxiong Chanfirstname.lastname@example.org||Personal web page|
Alzheimer's disease (AD) patients are 10 times more likely to develop epilepsy compared with age-matched controls. The treatment of recurrent seizures with conventional antiepileptic drugs may exacerbate cognitive decline. There are currently no treatments that prevent epilepsy in AD patients and the pathological basis for the increased risk of epilepsy is largely unknown Understanding the pathomechanisms of epileptogenesis in AD is crucial in identifying effective therapeutic strategies. This will help to prevent the development of epilepsy in this high risk and vulnerable population. This project aims to directly address the mechanisms of epileptogenesis in AD through the study of animal models of AD and acquired epilepsy. The aims will be achieved by subjecting transgenic AD models reflecting the pathological hallmarks to acquired epileptogenesis and treating them novel compounds. The phenotypic changes will be correlated with the molecular and cellular changes in these pathways.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research Group / Unit / Centre
Research NodeRoyal Melbourne Hospital
MDHS Research library
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