Acquired epilepsy in Alzheimer’s disease

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Professor Patrick Kwan patrick.kwan@unimelb.edu.au
Co-supervisor Email Number Webpage
Assoc Professor Nigel Jones Nigel.Jones@monash.edu
Dr Jianxiong Chan jianxiong.chan@unimelb.edu.au

Summary People with Alzheimer's disease (AD) are 10 times more likely to develop epilepsy compared with age-matched controls. Elucidating the pathomechanisms of epileptogenesis in AD is critical in identifying effective therapeutic strategies to prevent the development of epilepsy in this high risk and vulnerable population.

Project Details

People with Alzheimer's disease (AD) are 10 times more likely to develop epilepsy compared with age-matched controls. Recurrent seizures and their treatment with conventional antiepileptic drugs may exacerbate cognitive decline, yet the pathological basis for the increased risk of epilepsy is largely unknown, and there are no treatments that prevent epilepsy in AD patients. The relationships between the pathological processes of AD and neuronal hyperexcitability are poorly understood. Elucidating the pathomechanisms of epileptogenesis in AD is critical in identifying effective therapeutic strategies to prevent the development of epilepsy in this high risk and vulnerable population.  The novelty of this project lies in its aims to directly address the mechanisms of epileptogenesis in AD through the study of relevant animal models of AD and acquired epilepsy. It will identify the mechanistic processes of epileptogenesis in AD under a coherent hypothesis. The aims will be achieved by subjecting transgenic AD models reflecting the pathological hallmarks to acquired epileptogenesis and treating them novel compounds. The phenotypic changes (epileptogenesis and cognitive/behavioural outcomes) will be correlated with the molecular and cellular changes in these pathways



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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