A parallel group, blinded, placebo controlled, ranDomised pRagmatic clinical trial investigating the Effect of temazepAM on objective and subjective measures of sleep in critically ill patients (The DREAM trial)
- Research Opportunity
- Masters by Research
- Department / Centre
- Medicine and Radiology
- Royal Melbourne Hospital
|A/Prof Adam Deanefirstname.lastname@example.org||0393429254||Personal web page|
|Dr Yasmine Ali Abdelhamid||Yasmine.Aliabdelhamid@mh.org.au||0393429254|
Summary Sleep dysfunction (a reduction in quantity and quality) occurs frequently in the intensive care unit (ICU) and is associated with adverse outcomes. To improve sleep in the ICU patients are often prescribed a sleep aid medication, however, there is no evidence that these drugs actually work in the ICU setting. This randomised clinical trial will answer the question: Does temazepam (a frequently administered drug) affect sleep quality or total sleep time in critically ill patients?
Sleep dysfunction (a reduction in quantity and quality) occurs frequently in the intensive care unit (ICU) and is associated with adverse outcomes. To improve sleep in the ICU patients are often prescribed a sleep aid medication, and at the Royal Melbourne Hospital temazepam is the most frequently prescribed drug. These drugs are administered on the basis that they improve patient sleep quality and quantity, however there is no evidence that temazepam actually works in the ICU setting. Moreover, these drugs may have adverse effects.
The proposed study will provide novel data as it will be the first comprehensive assessment of the efficacy of temazepam on sleep quality and quantity, in patients admitted to ICU compared to placebo.
The DREAM trial is a prospective, parallel group, blinded, placebo-controlled, randomised, pragmatic clinical trial of 56 critically ill patients.
The primary null hypothesis is that a single dose of temazepam has no effect on total sleep time in critically ill patients as quantified by bedside nurse (subjective) assessment.
Who would be suited to this project?
As this is a clinical study it is best suited to a higher degree student who desires to study post-graduate medicine
Is completion of this project feasible?
The trial has HREC and governance approval and will commence enrolling patients in Oct 2020 to allow for completion during 2021
School Research Themes
Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research NodeRoyal Melbourne Hospital
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