A monoclonal antibody (mAb1F5) has been developed that identifies the expression of a putative growth factor
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- Austin Health
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The expression pattern identified by a novel antibody has been characterised in a number of foetal and adult tissues including pericytes associated with tumour vasculature, meningeal cells of the foetal brain and osteoblasts of developing bone. These observations are consistent with the identification of a novel (growth) factor that would also play an important role in foetal development, neuron homeostasis and tumourogenesis. The proposed strategy for the identification of this target protein will include the purification of the protein/peptide from an osteoblast or meningeal cell line and sequencing of peptide fragments using proteomics and further molecular studies.
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