The role of RNA editing enzyme ADAR1 in liver homeostasis and metabolism
- Research Opportunity
- PhD students, Masters by Research, Honours students, Post Doctor Researchers
- Number of Honour Places Available
- 1
- Number of Master Places Available
- 1
- Department
- Medicine and Radiology
- Location
- St Vincent's Institute of Medical Research
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| A/Prof Carl Walkley | cwalkley@svi.edu.au | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Jacki Heraud-Farlow | jhfarlow@svi.edu.au |
Summary We are interested in understanding how the RNA modifying enzyme ADAR1 functions. We will use genetic models to dissect its in vivo function.
Project Details
The gene ADAR1 is essential to perform a highly prevalent form of RNA modification termed A-to-I editing. Editing occurs primarily within repetitive elements in endogenous RNA that can fold to form immunogenic double-stranded RNA. When edited, this double-stranded RNA does not activate innate immune sensors. Mutation of ADAR1 however, leads to a profound upregulation of type I interferon in mice and humans and causes the severe auto-immune disease Aicardi-Goutieres syndrome. Recently, however, a novel function of Adar1 protein has been identified that is independent of its role in RNA editing. Preliminary results suggest a function in the liver to maintain normal metabolism.
This project seeks to further investigate this function using mouse genetics, cell culture, RNA sequencing and biochemical techniques.
Faculty Research Themes
Cancer, Infection and Immunology
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students, Post Doctor Researchers
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Research Node
St Vincent's Institute of Medical ResearchMDHS Research library
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