The role of RNA editing enzyme ADAR1 in liver homeostasis and metabolism

Research Opportunity
PhD students, Masters by Research, Honours students, Post Doctor Researchers
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Medicine and Radiology
Location
St Vincent's Institute of Medical Research
Primary Supervisor Email Number Webpage
A/Prof Carl Walkley cwalkley@svi.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Jacki Heraud-Farlow jhfarlow@svi.edu.au

Summary We are interested in understanding how the RNA modifying enzyme ADAR1 functions. We will use genetic models to dissect its in vivo function.

Project Details

The gene ADAR1 is essential to perform a highly prevalent form of RNA modification termed A-to-I editing. Editing occurs primarily within repetitive elements in endogenous RNA that can fold to form immunogenic double-stranded RNA. When edited, this double-stranded RNA does not activate innate immune sensors. Mutation of ADAR1 however, leads to a profound upregulation of type I interferon in mice and humans and causes the severe auto-immune disease Aicardi-Goutieres syndrome. Recently, however, a novel function of Adar1 protein has been identified that is independent of its role in RNA editing. Preliminary results suggest a function in the liver to maintain normal metabolism.

This project seeks to further investigate this function using mouse genetics, cell culture, RNA sequencing and biochemical techniques.



Faculty Research Themes

Cancer, Infection and Immunology

School Research Themes

Cancer in Medicine



Research Opportunities

PhD students, Masters by Research, Honours students, Post Doctor Researchers
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Institute of Medical Research

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