Exploring how diabetes causes increased proliferation of haematopoietic stem cells carrying a mutation in DNMT3A

Research Opportunity
PhD students, Masters by Research, Honours students
Department / Centre
Baker Department of Cardiometabolic Health
Primary Supervisor Email Number Webpage
Prof Andrew Murphy andrew.murphy@baker.edu.au
Co-supervisor Email Number Webpage
Dr. Dragana Dragoljevic dragana.dragoljevic@baker.edu.au

Summary Clonal haematopoiesis of indeterminant potential (CHIP), caused by somatic mutations in haematopoietic stem cells (HSCs) causes a growth advantage in these cells causing them to outcompete non-mutated HSCs. CHIP was commonly thought to be a prerequisite to leukaemia, the disease ultimately responsible for death in these individuals. However, it was recently shown that people with CHIP more frequently die of cardiovascular disease. Interestingly, there is an association with CHIP and diabetes, but this has not been explored experimentally. We discovered that diabetes enhances the proliferation of HSCs carrying the most common mutation in CHIP (DNMT3A). This project will explore mechanism behind this using a variety of unique animal models and experimental techniques. This project will give the student a valuable insight into stem cell biology within a highly successful world class research laboratory.

Project Details

Faculty Research Themes

Cancer, Infection and Immunology

School Research Themes

Cancer in Medicine, Ageing, Cardiometabolic

Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

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