Musculoskeletal

Musculoskeletal diseases are identified as the second greatest cause of disability throughout the world and include conditions such as osteoporosis, sarcopenia and arthritis. Researchers are part of cross-functional and collaborative teams to study conditions related to disorders of the bone, muscle and joint for improvement in disease prevention and evidence-based care.

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Projects	Supervisor(s)	Department	Research Opportunity
A cytokine pathway in the control of inflammation and pain	John Hamilton	Medicine and Radiology	PhD students
Adipocytes as Weapons of Bone Destruction: The bone as a War Zone	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Analysis of Synovial Fluid and Peripheral Blood Samples from Patients with Rheumatoid Arthritis and Using Patients with Osteoarthritis as Controls	Keith Lim	Medicine and Radiology	PhD students, Masters by Research, Honours students
Associations Between Sarcopenia, Intramuscular Fat, Mental/Physical Function and Brain Atrophy: An Imaging and Machine Learning Approach	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Balance Gym for Falls Prevention in Older Adults	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Biofabrication of an in vitro 3D osteosarcoma model	Claudia di Bella Serena Duchi	Surgery	PhD students, Masters by Research, Honours students, Master of Biomedical Science
Bone Substrate Composition Affecting Bone Cell Formation, Function and Bone Turnover	Damian Myers	Medicine and Radiology	PhD students, Masters by Research, Honours students
CASE: Cartilage Analytic Screening Environment	Claudia di Bella Carmine Onofrillo	Surgery	PhD students, Masters by Research
Characterization of Osteosarcopenia in Older Persons: A Bench to Bedside Approach	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Controlled mechanical stimulation for cartilage regeneration modelling with 3D bioprinting techniques	Carmine Onofrillo	Surgery	PhD students, Masters by Research
Dendritic cell cutaneous egression in Mycobacterium ulcerans infection	John Hayman	Clinical Pathology	Honours students, Master of Biomedical Science
Development of Marrow Fat Quantification as a Predictor of Poor Outcomes in Osteosarcopenia	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Dynamic microfluidic in vitro differentiation of stem cells for cartilage regeneration in surgical 3D bioprinting	Carmine Onofrillo	Surgery	PhD students, Masters by Research
Effect of HMB and Vitamin D Supplementation on osteosarcoPenia In oldeR pErsons (EMPIRE)	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Effects of Vitamin D Status on DEXA Femoral Neck BMD in Children and Adolescents	Christine Rodda	Medicine and Radiology	PhD students, Masters by Research
Effects of Vitamin D Status on Forearm Fracture Healing Rates in Children and Adolescents: A Pilot Study	Christine Rodda	Medicine and Radiology	PhD students, Masters by Research
Elucidating molecular signalling pathways controlled by anti-inflammatory steroids	Adrian Achuthan	Medicine and Radiology	PhD students, Masters by Research, Honours students, Master of Biomedical Science
Elucidating the functional roles of CCL17 in obesity-associated osteoarthritis	Adrian Achuthan	Medicine and Radiology	PhD students
Field tests for evaluation and prognostication in interstitial lung disease	Yet Hong Khor	Medicine and Radiology	PhD students, Masters by Research, Honours students
Fighting disease with electricity: Vagus nerve stimulation as a treatment of arthritis	Sophie Payne	Medical Bionics Department	Honours students
Generation of an ex vivo regeneration model for 3D bioprinting applications	Carmine Onofrillo	Surgery	PhD students, Masters by Research
How are autophagic processes involved in bone mineralisation?	Natalie Sims	Medicine and Radiology	PhD students, Honours students
How does the periosteum control bone width?	Natalie Sims	Medicine and Radiology	Honours students
Inflammation-induced Osteosarcopenia: Mechanisms and Novel Treatments	Kulmira Nurgali	Medicine and Radiology	PhD students, Masters by Research, Honours students
Investigating Lipotoxic Impacts of Fatty Acid Synthesis on: (1) Osteoblasts, and (2) Osteoclast, in Vitro and (3) Skeletal Muscle	Damian Myers	Medicine and Radiology	PhD students, Masters by Research, Honours students
Investigating the Anabolic Effect Drugs (Picolinic Acid) on Osteocytes in Vitro	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Investigating the Rapamycin Effect on Induced-Palmitic osteocytes in Vitro	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Marrow Adipose Tissue Functions: Studying Lipotoxicity in Hip Replacement Candidates	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Mid-Thigh Bone and Muscle Mass Measurements as an Assessment Tool for Diagnosis of Osteoporosis/penia, Sarcopenia and Osteosarcopenia: A Longitudinal Validation Study	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Molecular signalling pathways controlling gene expression during chronic disease progression	Adrian Achuthan	Medicine and Radiology	PhD students, Masters by Research, Honours students, Master of Biomedical Science
Neural modelling of epileptic dynamics	Andre Peterson	Medicine and Radiology	PhD students, Masters by Research, Honours students, Master of Biomedical Science
Osteosarcopenia as a Geriatric Syndrome	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Osteosarcopenia assessment in resource-limited settings	Jesse Zanker	Medicine and Radiology	Honours students
Osteosarcopenia in community-dwelling older adults attending the Falls and Fracture Clinic	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Osteosarcopenia in Older Adults Attending a Fracture Liaison Service	David Scott	Medicine and Radiology	PhD students, Masters by Research
Pathology begins in the cells: Studying lipotoxic stress generated from adipocytes in bone and muscle cell cultures	Damian Myers	Medicine and Radiology	PhD students, Masters by Research, Honours students
Pre-clinical Analysis of Effects of Lamin A Overexpression on Mesenchymal Stem Cell Differentiation into Myocytes	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Pre-Clinical Studies Identifying Novel Molecular Regulators of Skeletal Muscle Growth and Atrophy	Alan Hayes	Medicine and Radiology	PhD students, Masters by Research, Honours students
Predicting Disability and Frailty in Older Persons: The Western Osteosarcopenia and Frailty (WOSF) Study	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Refining the comprehensive geriatric assessment	Andrea Maier	Medicine and Radiology	PhD students, Masters by Research, Honours students
Structural biology of proteins involved in bone diseases	Brett Bennetts	Medicine and Radiology	PhD students, Masters by Research, Honours students, Master of Biomedical Science
The Correlation between Knee Effusions and Clinical Presentation in Patients with Knee Osteoarthritis	Keith Lim	Medicine and Radiology	PhD students, Masters by Research, Honours students
The role of CCL17 in osteoarthritis	Kevin Lee	Medicine and Radiology	PhD students, Masters by Research, Honours students
Treatment outcome in older lung cancer patients: does the biological age predict it?	Andrea Maier	Medicine and Radiology	PhD students, Masters by Research, Honours students
Use of tools to detect medication related problems in emergency departments	Elizabeth Manias	Psychiatry	Honours students, Master of Biomedical Science
Using Marrow Adipose Tissue to Diagnose Osteoporosis and Predict Fragility Fractures	Gustavo Duque	Medicine and Radiology	PhD students, Masters by Research, Honours students
Using Wearable Activity Trackers to Monitor Physical Activity in Older Adults Undergoing Exercise Interventions for Falls	David Scott	Medicine and Radiology	PhD students, Masters by Research
Vascular remodeling in patients with Mycobacterium ulcerans infection and its effect on wound healing	John Hayman	Clinical Pathology	Honours students, Master of Biomedical Science
Vitamin D deficiency and balance	Monique Stagnitti	Medicine and Radiology
What controls the development of strong cortical bone?	Natalie Sims	Medicine and Radiology	PhD students, Honours students
Your Muscles Matter – The Sarcopenia Study	Alan Hayes	Medicine and Radiology	PhD students, Masters by Research, Honours students