Tumour suppressor functions of the IRF6/RIPK4 axis

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Melbourne Dental School
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au
Co-supervisor Email Number Webpage
Dr Jacqui Heath

Summary In this project, you will investigate the effects of cancer-associated mutations on the regulation and function of IRF6 by RIPK4. You will also identify novel proteins that interact with IRF6 and RIPK4.

Project Details

Many cancers, including skin, breast, and oral cancer, are caused by mutations that dysregulate the normal programs of epithelial cell proliferation and differentiation. The IRF6 transcription factor plays an important role in promoting normal epithelial cell differentiation. We have discovered that IRF6 is directly regulated by the protein kinase RIPK4, and shown that they function together as a regulatory axis to promote epithelial cell differentiation. Notably, IRF6 and RIPK4 were recently discovered to be mutated in human cancers of epithelial origin. In this project, you will investigate the effects of cancer-associated mutations on the regulation and function of IRF6 by RIPK4. You will also identify novel proteins that interact with IRF6 and RIPK4. The project will provide students with opportunities to develop skills in mammalian cell culture, mutagenesis & manipulating gene expression, mass spectrometry, gene expression analysis, immunofluorescence confocal microscopy, critical thinking & time management, scientific writing & oral communication.



Faculty Research Themes

Cancer

School Research Themes

Population and Oral Health



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Melbourne Dental School

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

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