Tumour suppressor functions of the IRF6/RIPK4 axis

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Melbourne Dental School
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au 9341 1545 Personal web page

Summary You will investigate the effects of cancer-associated mutations on the regulation and function of the IRF6 by RIPK4. The new knowledge you create will help us understand how dysregulation of IRF6 and RIPK4 can cause cancer.

Project Details

Many cancers, including oral, skin, and breast cancer, are caused by mutations that dysregulate the normal genetic program of epithelial cell differentiation. The IRF6 transcription factor plays an important role in promoting epithelial cell differentiation. We have discovered that IRF6 is directly regulated by the protein kinase RIPK4, and shown they function as a regulatory axis to promote epithelial cell differentiation. IRF6 and RIPK4 were recently shown to be mutated in some human cancers. In this project you will investigate the effects of cancer-associated mutations on the regulation and function of IRF6 by RIPK4. You will also identify novel regulatory proteins that interact with IRF6 and RIPK4. The new knowledge you create will help us understand how epithelial cancers develop.

This project will provide students with opportunities to develop skills in mammalian cell culture, mutagenesis and manipulating gene expression, mass spectrometry, gene expression analysis, immunofluorescence confocal microscopy, critical thinking and time management, scientific writing and oral communication, critical thinking and time management, scientific writing and oral communication.



Faculty Research Themes

Cancer

School Research Themes

Population and Oral Health



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Melbourne Dental School

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

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