Tumour suppressor functions of the IRF6/RIPK4 axis
- Research Opportunity
- Honours, Master of Biomedical Science
- Number of Honour Places Available
- Number of Master Places Available
- Melbourne Dental School
- Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
|A/Prof Glen Scholzfirstname.lastname@example.org|
|Dr Jacqui Heath|
Summary In this project, you will investigate the effects of cancer-associated mutations on the regulation and function of IRF6 by RIPK4. You will also identify novel proteins that interact with IRF6 and RIPK4.
Many cancers, including skin, breast, and oral cancer, are caused by mutations that dysregulate the normal programs of epithelial cell proliferation and differentiation. The IRF6 transcription factor plays an important role in promoting normal epithelial cell differentiation. We have discovered that IRF6 is directly regulated by the protein kinase RIPK4, and shown that they function together as a regulatory axis to promote epithelial cell differentiation. Notably, IRF6 and RIPK4 were recently discovered to be mutated in human cancers of epithelial origin. In this project, you will investigate the effects of cancer-associated mutations on the regulation and function of IRF6 by RIPK4. You will also identify novel proteins that interact with IRF6 and RIPK4. The project will provide students with opportunities to develop skills in mammalian cell culture, mutagenesis & manipulating gene expression, mass spectrometry, gene expression analysis, immunofluorescence confocal microscopy, critical thinking & time management, scientific writing & oral communication.
Faculty Research Themes
School Research Themes
Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeRoyal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
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