Identification and functional characterisation of novel partners of the IRF6 transcription factor

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Melbourne Dental School
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au

Summary In this project, you will use cell culture systems to identify and characterise novel binding partners of IRF6.

Project Details

The epithelial cells covering the external surfaces of the body (e.g. skin & oral cavity) not only function as an important physical barrier to infection but their expression of immune receptors also enables them to actively particulate in host defence. We have established that the IRF6 transcription factor is an important regulator of the host defence functions of epithelial cells. However, the proteins with which IRF6 interacts to regulate these important functions are poorly understood. In this project, you will use cell culture systems to identify and characterise novel binding partners of IRF6. The project will provide students with opportunities to develop skills in mammalian cell culture, mass spectrometry, manipulating gene expression, cell signalling & gene expression analysis, immunofluorescence confocal microscopy, critical thinking & time management, scientific writing & oral communication.



Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Melbourne Dental School

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

MDHS Research library
Explore by researcher, school, project or topic.