How the inflammatory cytokine IL-36 gamma prevents infection

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department
Melbourne Dental School
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au 9341 1545 Personal web page

Summary You will use gene knockout mice to understand how IL-36 gamma prevents infection by bacterial pathogens. The new knowledge you create will help us develop better ways to treat infections caused by antibiotic-resistant bacteria.

Project Details

The oral cavity is a major entry portal for bacterial pathogens. We recently discovered that the mucosal epithelial cells which line the oral cavity produce the novel inflammatory cytokine IL‑36 gamma in response to bacteria. Furthermore, we have shown that IL‑36 gamma not only stimulates the production of antimicrobial proteins, but also inflammatory cytokines that recruit immune cells (e.g. neutrophils and T-lymphocytes). In this project you will use gene knockout mice to understand how IL‑36 gamma prevents infection by bacterial pathogens. The new knowledge you create will help us develop better ways to treat infections caused by antibiotic-resistant bacteria.

This project will provide students with opportunities to develop skills in mouse models of bacterial infection, histological analysis, flow cytometry, mammalian and bacterial cell culture, gene silencing, cytokine analysis, immunofluorescence confocal microscopy, critical thinking and time management, scientific writing and oral communication.



Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Melbourne Dental School

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

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