How spatial control of cytokine responses maintains host-microbe homeostasis

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department
Melbourne Dental School
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au
Co-supervisor Email Number Webpage
Dr Jacqui Heath

Summary In this project, you will use cell culture systems to investigate how responses regulated by the cytokine IL-36 gamma are spatially controlled.

Project Details

The oral cavity encounters billions of bacteria, including potential pathogens, on a daily basis. Critically, the epithelial cells that line the oral cavity express receptors which enables the detection of bacteria. However, how the epithelial cells tolerate commensal bacteria, and yet produce cytokines that stimulate inflammation to eliminate pathogens is poorly understood. In contrast to pathogens, commensal bacteria do not typically invade epithelia. Therefore, the spatial control of cytokine-regulated responses likely plays a critical role in delineating between commensal bacteria and pathogens. In this project, you will use cell culture systems to investigate how responses regulated by the cytokine IL-36 gamma are spatially controlled. This project will provide important new insight into how impaired spatial regulation of IL-36 gamma could result in the stimulation of chronic inflammation by commensal bacteria and increased susceptibility to infection. The project will provide students with opportunities to develop skills in mammalian & bacterial cell culture, manipulating gene expression, cell signalling & transcriptional regulation, cytokine analysis, immunofluorescence confocal microscopy, critical thinking & time management, scientific writing & oral communication.



Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Melbourne Dental School

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

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