How mucosal epithelial cells tailor the host immune response to bacteria

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department
Melbourne Dental School
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au 9341 1545 Personal web page

Summary You will investigate how spatial regulation of inflammatory pathways facilitates appropriate tailoring of the host immune response to bacteria. The new knowledge you create will help us develop better ways to prevent bacterial-mediated diseases.

Project Details

The mucosal epithelial cells that line the oral cavity express receptors (e.g. Toll-like receptors) which detect bacteria. However, how mucosal epithelial cells tolerate commensal bacteria, and yet stimulate immune cells to kill pathogens, is poorly understood. The spatial context in which bacteria are detected by mucosal epithelial cells likely plays a critical role in enabling the cells to delineate commensal bacteria and pathogens. In this project you will investigate how spatial regulation of inflammatory pathways facilitates appropriate tailoring of the host immune response to bacteria. The new knowledge you create will help us develop better ways to prevent bacterial-mediated diseases.

This project will provide students with opportunities to develop skills in mouse models of bacterial infection, histological analysis, flow cytometry, mammalian and bacterial cell culture, gene silencing, cytokine analysis, immunofluorescence confocal microscopy, critical thinking and time management, scientific writing and oral communication.



Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Melbourne Dental School

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

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