How epithelial cells differentially tailor the immune response to commensal bacteria and pathogens

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Location
Bio21 Molecular Science and Biotechnology Institute,Royal Dental Hospital Melbourne
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au 9341 1545 Personal web page

Summary You will investigate how spatial regulation of inflammatory pathways facilitates appropriate tailoring of the host immune response to bacteria. The new knowledge you create will help us to develop better ways to prevent bacteria-induced diseases.

Project Details

The epithelial cells that line the oral cavity express immune receptors which enable them to detect the presence of bacteria. However, how epithelial cells tolerate the presence of commensal bacteria and yet stimulate host inflammation to prevent infection by bacterial pathogens is poorly understood. The spatial context in which bacteria are detected by epithelial cells likely plays a critical role in enabling them to discriminate between commensal bacteria and pathogens. In this project you will investigate how the spatial regulation of inflammatory pathways enables the tailoring of the host immune response to bacteria. The project will provide opportunities to develop skills in mammalian and bacterial cell culture, manipulating gene expression, analysis of cell signalling and gene expression, immunofluorescence confocal microscopy, critical thinking, scientific writing, and oral communication.



Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Research Node

Bio21 Molecular Science and Biotechnology Institute,Royal Dental Hospital Melbourne

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